Vetina KBR Tablet 500 mg
Description :
Bromides are used both as primary therapy and as adjunctive therapy to control seizures in dogs that are not adequately controlled by phenobarbital alone.
While historically bromides were only recommended for use alone in patients suffering from phenobarbital hepatotoxicity, bromides are more frequently used as a drug of first choice.
Indications:
- Seizures,
- Anxiety
Composition
Each uncoated tablet contains:
Potassium bromide I.P.………500 mg
Cyanocobalamin I.P.……………10 mcg
Excipients……………………………q.s.
Meat Flavoured
CLINICAL PHARMACOLOGY:
Bromide’s anti-seizure activity is thought to be the result of its generalized depressant effects on neuronal excitability and activity. Bromide ions compete with chloride transport across cell membranes resulting in membrane hyperpolarization, thereby raising seizure threshold and limiting the spread of epileptic discharges
CONTRAINDICATIONS:
VETINA KBR TM should not be used in animals with a history of hypersensitivity to Bromide or any of the components of the solution or tablet.
ADVERSE REACTIONS:
Dog may experience drowsiness when taking bromide, but this will generally go away after approximately 3 weeks. Increased hunger, thirst, urination, vomiting, constipation, anorexia, and uncoordinated movements may occur with bromide. During the load in dose increased nausea may be experienced
Presentation:
1×10 Tablets
Dosage :
Drug |
Dosage and Frequency |
Half Life |
Time to Steady State |
Therapeutic level |
Adverse Effect / Comments |
Bromide (potassium salt) |
Dogs, cats: 20–40 mg/kg, PO, once daily or divided bid if GI upset. Caution using bromide in cats (see comments). Dogs: loading dose 400–600 mg/kg, PO divided into 4 doses, given over 1–4 days |
Dogs: 20–46 days Cats: 10days Horses: 5 days |
Dogs: 100–200 days Cats: 6 wk |
Bromide alone: 1–3 mg/mL (15–20 μmol/L) Bromide/phenobarbital combined: 1–2 mg/mL |
Sedation,weakness, polydipsia, vomiting, polyphagia, skin rash. Reduce dose with renal insufficiency. High chloride intake increases bromide elimination. Chloride content of diet should be stable. Use with extreme caution in cats and monitor with thoracic radiographs because bronchial/asthmatic signs may be fatal in cats. |
Vetina’s KBR Tablet Dosing |
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To achieve a serum level of approximately 1 mg/mL, give 120 mg/kg PO daily for 5 days | Dose reduction to 30 mg/kg PO once daily. | For seizures: 400 – 600 mg/kg/day divided and given with food. May be given over 24 hours or more gradually over 5 days. Then go to initial maintenance dose: 20 – 30 mg/kg PO once daily | |||
For Giving 120 mg /kg daily : | For Giving 30 mg /kg daily : | For Giving 500 mg /kg daily : | |||
Wt of Dog taken 10 Kgs | Wt of Dog taken 10 Kgs | Wt of Dog taken 10 Kgs | |||
Concentration of drug is 500 mg | Concentration of drug is 500 mg | Concentration of drug is 500 mg | |||
Dose Calculation | Dose Calculation | Dose Calculation | |||
120 mg X 10 kgs = 1200 mg (Dose requiremennt ) | 30 mg X 10 kgs = 300 mg (Dose requiremennt ) | 500 mg X 10 kgs = 5000 mg (Dose requiremennt ) | |||
1200/ 500 mg (Drug concentration ) | 300/ 500 mg (Drug concentration ) | 5000/ 500 mg (Drug concentration ) | |||
For 10 Kg Dog and Cat Dose = 2.5 tablet | For 10 Kg Dog and Cat Dose = 0.5 tablet | For 10 Kg Dog and Cat Dose =10 tablet | |||
Dosing as per Weight per day for 5 days |
Dosing as per Weight |
Dosing as per Weight for 5 days |
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Weight | Dose | Weight | Dose | Weight | Dose |
5 kg | 1.5 Tablet | 5 kg | 0.5 Tablet | 5 kg | 5 Tablet |
10 kg | 2.5 Tablet | 10 kg | 0.5 Tablet | 10 kg | 10 Tablet |
15 kgs | 3.5 Tablet | 15 kgs | 1 Tablet | 15 kgs | 15 Tablet |
20 kgs | 5 Tablets | 20 kgs | 1.5 Tablet | 20 kgs | 20 Tablets |
25 kgs | 6 Tablets | 25 kgs | 1.5 Tablet | 25 kgs | 25 Tablet |
30 kgs | 7.5 Tablet | 30 kgs | 2 Tablet | 30 kgs | 30 Tablet |
35 kgs | 8.5 Tablet | 35 kgs | 2 Tablet | 35 kgs | 35 Tablet |
40 kgs | 9.5 Tablet | 40 kgs | 2.5 Tablet | 40 kgs | 40 Tablet |
45 kgs | 11 Tablets | 45 kgs | 3 Tablet | 45 kgs | 45 Tablet |