VETINA KBR Suspension -250 MG

Composition

Each ml contains:
Potassium bromide I.P.………250 mg
Cyanocobalamin I.P.…………….5 mcg
Pyridoxine Hydrochloride I.P.…..5 mg
Suspension base…………………q.s.

Flavour: Butterscotch, vanilla.

Indications:

Seizures,

Anxiety

Presentation:

Bottle of 60 ml

Mechanism of action:

The exact mechanism of anticonvulsant action of bromide is incompletely understood.
The action appears to involve chloride ion channels which are an important part of the inhibitory neuronal network of the CNS.

Their function is modulated by GABA. Increased chloride ion flow, as a result of activation of GABA receptors by barbiturates or benzodiazepines, results in increased neuronal inhibition and increases the threshold for seizures.

Bromide appears to cross neuronal chloride channels more readily than chloride because it has a smaller hydrated diameter. By competing with chloride ions, bromide hyperpolarizes postsynaptic neuronal membranes and facilitates the action of inhibitory neurotransmitters.

Barbiturates may act synergistically with bromide to raise the seizure threshold by enhancing chloride conductance via GABA-ergic activity.

Dosage :

Dogs:

To achieve a serum level of approximately 1 mg/mL, give 120 mg/kg PO daily for 5 days then reduce 30 mg/kg PO once daily. To achieve a serum level of approximately 1.5 mg/mL, give 160 mg/kg PO for 5 days and then reduce to 40 mg/kg PO once daily thereafter.

For seizures: 400 – 600 mg/kg/day divided and given with food. May be given over 24 hours or more gradually over 5 days. Then go to initial maintenance dose: 20 – 30 mg/kg PO once daily.

For idiopathic epilepsy: 100 mg/kg (q6h) for the first 24 hours, or 100 mg/kg (q24h) for 4 days. Maintenance dose: 35 – 40 mg/kg PO once daily (q24h). Serum KBr concentrations at 8 weeks, 12 weeks and every 6 months thereafter

Cats:

As third choice (after phenobarbital and diazepam) therapy of refractory seizures: 10 – 20 mg/kg/day PO. Follow same guideline as dogs.
As second line therapy for epilepsy: 30 mg/kg PO once daily.

Vetina’s KBR Suspension Dosing
To achieve a serum level of approximately 1 mg/mL, give 120 mg/kg PO daily for 5 days		Dose reduction to 30 mg/kg PO once daily.		For seizures: 400 – 600 mg/kg/day divided and given with food. May be given over 24 hours or more gradually over 5 days. Then go to initial maintenance dose: 20 – 30 mg/kg PO once daily
For Giving 120 mg /kg daily :		For Giving 30 mg /kg daily :		For Giving 500 mg /kg daily :
Wt of Dog taken 10 Kgs		Wt of Dog taken 10 Kgs		Wt of Dog taken 10 Kgs
Concentration of drug is 250 mg /ml		Concentration of drug is 250 mg /ml		Concentration of drug is 250 mg /ml

Dose Calculation		Dose Calculation		Dose Calculation
120 mg X 10 kgs = 1200 mg (Dose requiremennt )		30 mg X 10 kgs = 300 mg (Dose requiremennt )		500 mg X 10 kgs = 5000 mg (Dose requiremennt )
1200/ 250 mg (Drug concentration )		300/ 250 mg (Drug concentration )		5000/ 250 mg (Drug concentration )
For 10 Kg Dog and Cat Dose = 4.8 ml		For 10 Kg Dog and Cat Dose =1.2ml		For 10 Kg Dog and Cat Dose =20 ml

Dosing as per Weight per day for 5 days		Dosing as per Weight		Dosing as per Weight
Weight	Dose	Weight	Dose	Weight	Dose
5 kg	2.4 ml	5 kg	0.6 ml	5 kg	10 ml
10 kg	4.8 ml	10 kg	1.2 ml	10 kg	20 ml
15 kgs	7.2 ml	15 kgs	1.8 ml	15 kgs	30 ml
20 kgs	9.6 ml	20 kgs	2.4 ml	20 kgs	40 ml
25 kgs	12 ml	25 kgs	3 ml	25 kgs	50 ml
30 kgs	14.4 ml	30 kgs	3.6 ml	30 kgs	60 ml
35 kgs	16.8 ml	35 kgs	4.2 ml	35 kgs	70 ml
40 kgs	19.2 ml	40 kgs	4.8 ml	40 kgs	80 ml
45 kgs	21.6 ml	45 kgs	5.4 ml	45 kgs	90 ml