Vetina’s Levetiracetam-500 mg Tablet
Levetiracetam is a drug within the Pyrolidine class that is used to treat various types of seizures stemming from epileptic disorders.
It is an anticonvulsant that works by decreasing abnormal activity in the brain helps to manage epilepsy in companion animals.
Levetiracetam may be useful as a antiseizure medication in dogs that are not well controlled with phenobarbital and bromides or when either bromides or phenobarbital are not tolerated.
Some evidence suggests that in dogs suffering from phenobarbital liver toxicity, the addition of levetiracetam will allow reduction of their phenobarbital dosage without increasing seizure frequency.
Prevention of seizures
Each film coated tablet contains:
Levetiracetam IP…………500 mg
Levetiracetam appears to prevent seizure activity via the selective inhibition of hypersynchronized epileptiform burst firing without affecting normal neuronal transmission.
Levetiracetam has also been shown to indirectly affect GABAergic neurotransmission (despite having no direct effect on GABAergic or glutamatergic receptors) and modulate ionic currents.
Levetiracetam is contraindicated in animals who have previously exhibited hypersensitivity to it or any of its components. It should be used with caution in animals with renal impairment; dosage amounts or dosing frequency changes should be considered.
Levetiracetam appears to be very well tolerated in the limited number of dogs treated. Changes in behavior and gastrointestinal effects could occur.
In cats, the drug appears to have a wide safety margin, but less clinical use has occurred in that species. Transient in – appetance has been reported in some cats receiving the drug.
Presentation: 10 x1x10 TAB
|Drug||Dosage and Frequency||Half Life||Time to Steady State||Therapeutic level||Adverse Effect / Comments|
|Levetiracetam||Dogs: 20 mg/kg, PO, tid||4–10 hr||2–3 days||35–120 μmol/La||Restlessness, vomiting, ataxia at dosages >400 mg/kg/day|