Vetina’s Levetiracetam-500 mg Tablet


Levetiracetam is a drug within the Pyrolidine class that is used to treat various types of seizures stemming from epileptic disorders.

Levetiracetam is a broad-spectrum anti-epileptic agent, which is routinely used as adjunct treatment, or as monotherapy

It is an anticonvulsant that works by decreasing abnormal activity in the brain helps to  manage epilepsy in companion animals.

Levetiracetam may be useful as a antiseizure medication in dogs that are not well controlled with phenobarbital and bromides or when either bromides or phenobarbital are not tolerated.

Some evidence suggests that in dogs suffering from phenobarbital liver toxicity, the addition of levetiracetam will allow reduction of their phenobarbital dosage without increasing seizure frequency.



Focal epilepsy

Partial-complex epilepsy

Generalized epilepsy

Prevention of seizures


Each film coated tablet contains:

Levetiracetam IP…………500 mg




Levetiracetam appears to prevent seizure activity via the selective inhibition of hypersynchronized epileptiform burst firing without affecting normal neuronal transmission.

Levetiracetam has also been shown to indirectly affect GABAergic neurotransmission (despite having no direct effect on GABAergic or glutamatergic receptors) and modulate ionic currents.


Levetiracetam is contraindicated in animals who have previously exhibited hypersensitivity to it or any of its components. It should be used with caution in animals with renal impairment; dosage amounts or dosing frequency changes should be considered.


Levetiracetam appears to be very well tolerated in the limited number of dogs treated. Changes in behavior and gastrointestinal effects could occur.

In cats, the drug appears to have a wide safety margin, but less clinical use has occurred in that species. Transient in – appetance has been reported in some cats receiving the drug.

Presentation:  10 x1x10 TAB


Drug Dosage and Frequency Half Life Time to Steady State Therapeutic level Adverse Effect / Comments
Levetiracetam Dogs: 20 mg/kg, PO, tid 4–10 hr 2–3 days 35–120 μmol/La Restlessness, vomiting, ataxia at dosages >400 mg/kg/day