Vetina’s Levetiracetam


  • Levetiracetam is a drug within the Pyrolidine class that is used to treat various types of seizures stemming from epileptic disorders. 
  • Levetiracetam is a broad-spectrum anti-epileptic agent, which is routinely used as adjunct treatment, or as monotherapy
  • It is an anticonvulsant that works by decreasing abnormal activity in the brain helps to  manage epilepsy in companion animals.
  • Levetiracetam may be useful as a antiseizure medication in dogs that are not well controlled with phenobarbital and bromides or when either bromides or phenobarbital are not tolerated. 
  • Some evidence suggests that in dogs suffering from phenobarbital liver toxicity, the addition of levetiracetam will allow reduction of their phenobarbital dosage without increasing seizure frequency.


  • Focal epilepsy
  • Partial-complex epilepsy
  • Generalized epilepsy
  • Prevention of seizures 


Each film coated tablet contains:

  • Levetiracetam IP…………500 mg
  • Excipients…………….…..q.s.


  • Levetiracetam appears to prevent seizure activity via the selective inhibition of hypersynchronized epileptiform burst firing without affecting normal neuronal transmission.
  • Levetiracetam has also been shown to indirectly affect GABAergic neurotransmission (despite having no direct effect on GABAergic or glutamatergic receptors) and modulate ionic currents. 


  • Levetiracetam is contraindicated in animals who have previously exhibited hypersensitivity to it or any of its components. It should be used with caution in animals with renal impairment; dosage amounts or dosing frequency changes should be considered. 


  • Levetiracetam appears to be very well tolerated in the limited number of dogs treated. Changes in behavior and gastrointestinal effects could occur.
  • In cats, the drug appears to have a wide safety margin, but less clinical use has occurred in that species. Transient in – appetance has been reported in some cats receiving the drug. 

Presentation:  10 x1x10 TAB



Dosage and Frequency 

Half Life

Time to Steady State

Therapeutic level 

Adverse Effect / Comments


Dogs: 20 mg/kg, PO, tid

4–10 hr

2–3 days

35–120 μmol/La

Restlessness, vomiting, ataxia at dosages >400 mg/kg/day