Vetina’s Levetiracetam

Description:

• Levetiracetam is a drug within the Pyrolidine class that is used to treat various types of seizures stemming from epileptic disorders. 
• Levetiracetam is a broad-spectrum anti-epileptic agent, which is routinely used as adjunct treatment, or as monotherapy
• It is an anticonvulsant that works by decreasing abnormal activity in the brain helps to  manage epilepsy in companion animals.
• Levetiracetam may be useful as a antiseizure medication in dogs that are not well controlled with phenobarbital and bromides or when either bromides or phenobarbital are not tolerated. 
• Some evidence suggests that in dogs suffering from phenobarbital liver toxicity, the addition of levetiracetam will allow reduction of their phenobarbital dosage without increasing seizure frequency.

Indications:

• Focal epilepsy
• Partial-complex epilepsy
• Generalized epilepsy
• Prevention of seizures 

Composition:

Each film coated tablet contains:

• Levetiracetam IP…………500 mg
• Excipients…………….…..q.s.

CLINICAL PHARMACOLOGY:

• Levetiracetam appears to prevent seizure activity via the selective inhibition of hypersynchronized epileptiform burst firing without affecting normal neuronal transmission.
• Levetiracetam has also been shown to indirectly affect GABAergic neurotransmission (despite having no direct effect on GABAergic or glutamatergic receptors) and modulate ionic currents. 

CONTRAINDICATIONS:

• Levetiracetam is contraindicated in animals who have previously exhibited hypersensitivity to it or any of its components. It should be used with caution in animals with renal impairment; dosage amounts or dosing frequency changes should be considered. 

ADVERSE REACTIONS:

• Levetiracetam appears to be very well tolerated in the limited number of dogs treated. Changes in behavior and gastrointestinal effects could occur.
• In cats, the drug appears to have a wide safety margin, but less clinical use has occurred in that species. Transient in – appetance has been reported in some cats receiving the drug. 

Presentation:  10 x1x10 TAB

Dosage: