Pentorse 100

Injectable For Canines suffering from Osteoarthritis.

What is Pentorse 100?

Pentorse is made of an active ingredient called Pentosan polysulfate sodium. It is a semi-synthetic polysulfated polysaccharide.

PENTORSE  100 Canine Injection aids in the treatment of non-infectious, inflammatory joint disease in dogs.

Pentosan Polysulphate  is derived from a plant source called beechwood.

MAJOR CAUSES OF OA:

• Larger breeds such as German Shepherd , Labs, Golden Retrievers, Great Danes.
• Obesity
• Age
• Repetitive stress from athletic activities
• Mechanical Injuries.
• Improper Nutrition
• Genetics

INDICATIONS

• Osteo-arthritis & Traumatic joint disease
• Osteo-chondrosis dessicans
• Degenerative cartilaginous joint disease
• Musculoskeletal Disorder.
• Peri-articular Inflammation

BENEFITS OF PENTORSE

• Completely safe and no reported side effects
• Anti-inflammatory Action helps reducing joint inflammation and pain.
• Fibrinolytic Activity
• Chondroprotective action and inhibition of loss of proteoglycans helps in terminating further destruction of the joint and initiates regeneration of the damaged tissue.
• Stimulation of Hyaluronic Acid increases formation of synovial fluid which helps in lubrication of the joint.
• Inhibition of Destructive Enzymes
• Reverses effects of Osteoarthritis
• Technically the product shows a long-term effect as compared to other treatment options

CONTRADICTIONS

• Pentosan being a plant-based origin it doesn’t have any side effects in the body but occasionally if a patient is hypersensitive they may show gastric sensitivity like Emesis, diarrhoea, lethargy and anorexia.
• We also need to take precautions in the following cases:
• Do not use for the treatment of septic arthritis. In this case, appropriate antimicrobial therapy should be instigated.
• Do not use in dogs with advanced liver or kidney impairment, or evidence of infection.
• Do not use in dogs with blood disorders, coagulation disorders, bleeding or malignancy (especially haemangiosarcoma).
• Pentosan Polysulfate has an anticoagulant effect. Do not use during the pre-operative period.
• Do not use in the skeletally immature dog (i.e. dogs whose long bone growth plates have not closed).
• Do not administer in Pregnant or lactating bitches.
• NSAID and In particular Aspirin should not  be used in combination with pentosan as they may affect thrombocyte adhesion and potentiate anticoagulant activity of the product.
• Corticosteroid have been shown to be antagonist to a number of action of  pentosan.

Dosage of Pentorse 100

• The dosage for canine is 3mg/kg BW (1 ml per 33 kg BW) given subcutaneously every 5-7 days for a period of 4 weeks.
• Can be repeated again after one month rest period.
•  Not more than 3 courses a year i.e 12 injections in a year.