Injectable For Canines suffering from Osteoarthritis.
What is Pentorse 100?
Pentorse is made of an active ingredient called Pentosan polysulfate sodium. It is a semi-synthetic polysulfated polysaccharide.
PENTORSE 100 Canine Injection aids in the treatment of non-infectious, inflammatory joint disease in dogs.
Pentosan Polysulphate is derived from a plant source called beechwood.
MAJOR CAUSES OF OA:
- Larger breeds such as German Shepherd , Labs, Golden Retrievers, Great Danes.
- Repetitive stress from athletic activities
- Mechanical Injuries.
- Improper Nutrition
- Osteo-arthritis & Traumatic joint disease
- Osteo-chondrosis dessicans
- Degenerative cartilaginous joint disease
- Musculoskeletal Disorder.
- Peri-articular Inflammation
BENEFITS OF PENTORSE
- Completely safe and no reported side effects
- Anti-inflammatory Action helps reducing joint inflammation and pain.
- Fibrinolytic Activity
- Chondroprotective action and inhibition of loss of proteoglycans helps in terminating further destruction of the joint and initiates regeneration of the damaged tissue.
- Stimulation of Hyaluronic Acid increases formation of synovial fluid which helps in lubrication of the joint.
- Inhibition of Destructive Enzymes
- Reverses effects of Osteoarthritis
- Technically the product shows a long-term effect as compared to other treatment options
- Pentosan being a plant-based origin it doesn’t have any side effects in the body but occasionally if a patient is hypersensitive they may show gastric sensitivity like Emesis, diarrhoea, lethargy and anorexia.
- We also need to take precautions in the following cases:
- Do not use for the treatment of septic arthritis. In this case, appropriate antimicrobial therapy should be instigated.
- Do not use in dogs with advanced liver or kidney impairment, or evidence of infection.
- Do not use in dogs with blood disorders, coagulation disorders, bleeding or malignancy (especially haemangiosarcoma).
- Pentosan Polysulfate has an anticoagulant effect. Do not use during the pre-operative period.
- Do not use in the skeletally immature dog (i.e. dogs whose long bone growth plates have not closed).
- Do not administer in Pregnant or lactating bitches.
- NSAID and In particular Aspirin should not be used in combination with pentosan as they may affect thrombocyte adhesion and potentiate anticoagulant activity of the product.
- Corticosteroid have been shown to be antagonist to a number of action of pentosan.
Dosage of Pentorse 100
- The dosage for canine is 3mg/kg BW (1 ml per 33 kg BW) given subcutaneously every 5-7 days for a period of 4 weeks.
- Can be repeated again after one month rest period.
- Not more than 3 courses a year i.e 12 injections in a year.