Vetina KBR Tablet 500 mg

1,800.00

Description :

Bromides are used both as primary therapy and as adjunctive therapy to control seizures in dogs that are not adequately controlled by phenobarbital alone.

While historically bromides were only recommended for use alone in patients suffering from phenobarbital hepatotoxicity, bromides are more frequently used as a drug of first choice.

Indications:

  • Seizures,
  • Anxiety 

Composition:

Each uncoated tablet contains:

  • Potassium bromide I.P.………500 mg
  • Cyanocobalamin I.P.……………10 mcg
  • Excipients……………………………q.s.

Meat Flavoured.

CLINICAL PHARMACOLOGY:

Bromide’s anti-seizure activity is thought to be the result of its generalized depressant effects on neuronal excitability and activity. Bromide ions compete with chloride transport across cell membranes resulting in membrane hyperpolarization, thereby raising seizure threshold and limiting the spread of epileptic discharges

CONTRAINDICATIONS:

VETINA KBR TM should not be used in animals with a history of hypersensitivity to Bromide or any of the components of the solution or tablet.

ADVERSE REACTIONS:

Dog may experience drowsiness when taking bromide, but this will generally go away after approximately 3 weeks. Increased hunger, thirst, urination, vomiting, constipation, anorexia, and uncoordinated movements may occur with bromide. During the load in dose increased nausea may be experienced

Presentation: Pack of 60 Tablets

Dosage :

Drug

Dosage and Frequency 

Half Life

Time to Steady State

Therapeutic level 

Adverse Effect / Comments

Bromide (potassium salt)

Dogs, cats: 20–40 mg/kg, PO, once daily or divided bid if GI upset. Caution using bromide in cats (see comments).

Dogs: loading dose 400–600 mg/kg, PO divided into 4 doses, given over 1–4 days

Dogs: 

20–46 days

Cats: 10days

Horses: 5 days

Dogs: 100–200 days

Cats: 6 wk

Bromide alone: 1–3   mg/mL (15–20 μmol/L)

Bromide/phenobarbital combined: 1–2 mg/mL

Sedation,weakness, polydipsia, vomiting, polyphagia, skin rash. Reduce dose with renal insufficiency. High chloride intake increases bromide elimination. Chloride content of diet should be stable. Use with extreme caution in cats and monitor with thoracic radiographs because bronchial/asthmatic signs may be fatal in cats.

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